Episode 148: Definitively vague questions with vaguely definitive answers – PART II
In episode 148, Mike and James return to the town of Questionville and attempt to answer riddles from near and far. Despite Mike having a cold, we tackle long acting insulins, exercise, multivitamins and varenecline with near Herculean-like abilities but provide answers that are much more on the mere-mortal side.
Show notes
1) Long acting insulins
CADTH report Long-Acting Insulin Analogues for the Treatment of Diabetes Mellitus
Tools for Practice – The long and short of long acting insulin analogues (versus NPH)
2) Activity
QoL stuff
Arch Intern Med 2009;169:269-278
Pedometers
Can Fam Physician 2010;56:887
Exercise Improves: Sleep, osteoarthritis pain, depression, obesity, glucose, lipids, BP
Cochrane 2002;CD003404
J Gerontol A Biol Sci Med Sci 2008;63:997-1004
J Sports Med Phys Fitness 2007;47:462-7
Cochrane 2008:CD004366
Cochrane 2008:CD004376
Inactivity a bigger risk than weight
J Am Geriatr Soc 2010;58:234–241
Activity and mortality
Arch Intern Med 2007;167:2453-2460
JAMA 2003;289:2379-2386
NEJM 2002;347:716-25
JAMA 1995;273:1093-8
Circulation 2008;117: 614-622
PLOS 2008;5: e12.
More activity, better
Br J Sports Med 2008;42:238–243
NEJM 1999;341:650-8
Eur J Epidemiol 2009;24:181–192
RCT of activity vs angioplasty
Circulation 2004;109:1371-8
3) Multivitamin Evidence
A & E harmful
Can Fam Physician 2005;51:1471-2
Multivitamins unnecessary(among first to be stopped in polypharmacy)
JAMA 2010;304:1592-1601
Vitamin B increases mortality
4) Vitamin D
Vitamin D problems
JAMA 2010;303:1815-1822
Rheumatology 2007;46:1852–1857
Regular dose reduces mortality
Cochrane:CD007470
Reduces falls
BMJ 2009;339:b3692 doi:10.1136/bmj.b3692
Cochrane:CD007146
For fractures (yes with Ca+, unsure otherwise)
Cochrane:CD000227
Re-evaluating the whole reference range
J Clin Endocrinol Metab 2011;96:53–58
5) Calcium evidence
Can Fam Physician 2011;57:798
6) Varenicline for smoking cessation
Cardiovascular events
Pharmacotherapy for smoking cessation
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