TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 397: Monoclonal antibodies – trying to put these agents into context

In episode 397, James and Mike discuss the evidence around the class of medications called monoclonal antibodies. We talk a little bit about them as a whole and then talk specifically about 6 different agents and the trials that have looked at the effectiveness of these interesting new medications. We come to the conclusion that you need to treat these agents, just like any new medication, by looking at the best available evidence.

Show notes

Handout for MABs

Episode 396: PREMIUM – studies about blood pressure and bone density

In episode 396, Mike and James present PREMIUM information from a premium province (BC). We discuss new studies that looked at measurements of blood pressure and bone density. At the end we put all of this information into a premium perspective.

Show notes

Tools for Practice

1) Association of Repeated Measurements With Blood Pressure Control in Primary Care

JAMA Internal Medicine 2018;178:858-60

2) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial

Lancet 2018;391:741-7

Episode 392: Aspirin – two more large and maybe unnecessary trials

In episode 392, James and Mike get back to work after a European tour and other reasons. We go over the results from the latest large aspirin trials and, low and behold, the results show pretty much what we already knew. 

Show notes

1) Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial.

Lancet 2018 Aug 24. pii: S0140-6736

2) Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

N Engl J Med. 2018 Aug 26. doi: 10.1056/NEJMoa1804988

3) The best CVD risk calculator


Episode 391: PREMIUM – 3 studies that will leave you short of breath

In episode 391, Mike and James have yet again a PREMIUM moment that will leave you short of breath. We go over 2 new studies that looked at asthma action plans and does increasing doses of inhaled corticosteroids work. In the last study we go over a comparison of vaginal estradiol, vaginal moisturizer or placebo for perimenopausal vulvovaginal symptoms, and placebo ends up working as well as anything else.

Show notes

1) Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations

N Engl J Med 2018;378:891-901

2) Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations

N Engl J Med 2018;378:902-910

3) Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms

JAMA Intern Med. doi:10.1001/jamainternmed.2018.0116

Episode 390: A shared-decision is the only outcome that matters in EBP

In episode 390, James and Mike have a discussion about how a shared-decision may be the only real outcome to measure if one is doing, or evaluating, evidence-based practice. Do our arguments convince you? Have we missed something important? Is this the best podcast ever on shared-decision making? Do you think we should be locked up? We would love feedback.

Show notes

Shared decision is the only outcome that matters when it comes to evaluating evidence-based practice

BMJ Evid Based Med 2018 Jul 12

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BS Medicine Podcast

The 2024 MEME Conference – May 24-25, 2024


Making Evidence Matter For Everyone | May 24 & 25, 2024
From the clinicians who brought you the Best Science Medicine Course and the Meds Conference, as well as the BS Medicine Podcast and Tools for Practice




Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.


BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

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