In episode 389, Mike and James go over with Adrienne Lindblad the evidence for a simple treatment for beast engorgement. Who knew that cabbage leaves worked for breast engorgement? At the end of the podcast we decide to attach cabbage leaves to all our microphones all the time, just in case – see last podcast description for context.
Show notes
Tools for Practice
Is that cabbage in your bra? Cabbage leaves for breast engorgement
In episode 388, Mike and James go over with Adrienne Lindblad the evidence for a simple treatment for nausea and vomiting in the ER. Who knew that inhaling isopropyl alcohol worked for nausea and vomiting? – possibly as good as the medications we have used in the past. At the end of the podcast we decide to attach isopropyl alcohol swabs to all our microphones all the time, just in case.
Show notes
Tools for Practice
Smell This: Isopropyl alcohol for nausea/vomiting in the emergency department
In episode 387, Mike and James go over the best available evidence for opioids in neuropathic pain. As with many pain treatments the evidence suggests there is some benefit and also some harm. Overall, it seems a reasonable approach would be to only use opioids in patients with refractory pain after multiple therapeutic trials with other agents.
Show notes
1) Tools For Practice
Nerve-ous About Opioids? Treatment of neuropathic pain with opioids
In episode 386, James and Mike talk about the latest low fat low carb weight loss study and then put it all into context of the more global evidence for low carbs vs low fats. The bottom line is, the evidence is even lower than the carbohydrates in a ketogenic diet – which is pretty low – or in other words nobody can really say what is the best diet – except maybe the one to which you will adhere.
Show notes
1) Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial
JAMA. 2018 Feb 20;319(7):667-679
2) Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials
Br J Nutr. 2016 Feb 14;115(3):466-79
3) Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study
J Intern Med. 2007 Apr;261(4):366-74
4) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
In episode 385, James and Mike invite Tim Caulfield (author, professor and lawyer) yet again to talk about the marketing and evidence around stem cell therapies. Low and behold the evidence pales in comparison to the hype. At the end Tim states – “science is hard” – enough said.
1) Is Gwenyth Paltrow wrong about everything?
2) A user’s guide to cheating death
3) Televised medical talk shows–what they recommend and the evidence to support their recommendations: a prospective observational study
BMJ. 2014 Dec 17;349:g7346. doi: 10.1136/bmj.g7346
4) The evolution of policy issues in stem cell research: an international survey
Stem Cell Rev. 2012 Dec;8(4):1037-42. doi: 10.1007/s12015-012-9404-5
5) Reassessing direct-to-consumer portrayals of unproven stem cell therapies: is it getting better?
Regen Med. 2013 May;8(3):361-9. doi: 10.2217/rme.13.15
6) International Society for Stem Cell Research
7) Polar Extremes in the Clinical Use of Stem Cells
N Engl J Med. 2017 Mar 16;376(11):1075-1077. doi: 10.1056/NEJMe1701379
8) How Anecdotal Evidence Can Undermine Scientific Results
9) Exploiting science? A systematic analysis of complementary and alternative medicine clinic websites’ marketing of stem cell therapies
In episode 384, James and Mike invite Tim Caulfield (author, professor and lawyer) to talk about the marketing of personalized medicine. We find out that most of the marketing is absurd. We also figure out that personalized medicine is being done all the time but it rarely if ever requires knowledge of any genetic testing results.
1) Is Gwenyth Paltrow wrong about everything?
2) A user’s guide to cheating death
3) Shattuck lecture–medical and societal consequences of the Human Genome Project
4) Representing a “revolution”: how the popular press has portrayed personalized medicine
Genet Med 2018 Jan 4. doi: 10.1038/gim.2017.217
5) Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial
Diabetes Care 2013 Jan;36(1):13-9. doi: 10.2337/dc12-0884
6) Genetic determinants of common obesity and their value in prediction.
Best Pract Res Clin Endocrinol Metab. 2012 Apr;26(2):211-26. doi: 10.1016/j.beem.2011.11.003.
7) Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis
Tob Control 2012 May;21(3):347-54. doi: 10.1136/tc.2011.042739
8) Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial
Clin Gastroenterol Hepatol. 2015 Sep;13(9):1625-1632.e1. doi: 10.1016/j.cgh.2015.02.044
9) Gene Environment Risk Assessment and Colorectal Cancer Screening in an Average Risk Population: A Randomized, Controlled Trial
Ann Intern Med. 2014 Oct 21; 161(8): 537–545.
10) Lifestyle Advice Combined with Personalized Estimates of Genetic or Phenotypic Risk of Type 2 Diabetes, and Objectively Measured Physical Activity: A Randomized Controlled Trial
PLoS Med. 2016 Nov 29;13(11):e1002185. doi: 10.1371/journal.pmed.1002185. eCollection 2016 Nov
11) Born Fat: The Relations Between Weight Changeability Beliefs and Health Behaviors and Physical Health
Health Educ Behav. 2016 Jun;43(3):337-46. doi: 10.1177/1090198115602266. Epub 2015 Sep 8
12) The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis
BMJ. 2016 Mar 15;352:i1102. doi: 10.1136/bmj.i1102
13) Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study
PLoS Med. 2014 May 20;11(5):e1001647. doi: 10.1371/journal.pmed.1001647. eCollection 2014 May
14) Why Are Some Population Interventions for Diet and Obesity More Equitable and Effective Than Others? The Role of Individual Agency
PLoS Med. 2016 Apr 5;13(4):e1001990. doi: 10.1371/journal.pmed.1001990. eCollection 2016 Apr
In episode 383, James and Mike go over the IMPACT trial that looks at triple inhaler therapy for patients with COPD. We talk about how, unfortunately, the impact is not that impactful and then put all the results into context with the issues of placebo, patents and cost.
Show Notes
1) Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD
2) Price Comparison of Commonly Prescribed Pharmaceuticals in Alberta 2018
In episode 382, Mike and James and Gary Bloch decide to try to solve the problem of poverty. While we get somewhere, it becomes clear that it might take more than just doing a 30-minute podcast. Who would have thought? Nonetheless, we hope that some of the things we discuss will inspire others to continue the battle against this extremely important health issue.
Show notes
2) The Clinical Tool on Poverty
3) A novel income security intervention to address poverty in a primary care setting: a retrospective chart review
4) Building a Foundation to Reduce Health Inequities: Routine Collection of Sociodemographic Data in Primary Care.
J Am Board Fam Med 2016;29:348-55
5) Framework for building primary care capacity to address the social determinants of health
Can Fam Physician 2017;63:e476-e482
6) What is the impact on individual health of services in general practice settings which offer welfare benefits advice?
Health Soc Care Community 2006;14:1–8
7) UK Social Prescribing – evidence
8) Taking action on the social determinants of health in clinical practice: a framework for health professionals
In episode 381, Mike and James invite Gary Bloch to talk in detail about the impact of poverty on health, and more importantly what can we do about it for our patients. In particular, we start to discuss a very useful clinical tool for dealing with poverty in primary care.
Show notes
2) The Clinical Tool on Poverty
3) A novel income security intervention to address poverty in a primary care setting: a retrospective chart review
4) Building a Foundation to Reduce Health Inequities: Routine Collection of Sociodemographic Data in Primary Care.
J Am Board Fam Med 2016;29:348-55
5) Framework for building primary care capacity to address the social determinants of health
Can Fam Physician 2017;63:e476-e482
6) What is the impact on individual health of services in general practice settings which offer welfare benefits advice?
Health Soc Care Community 2006;14:1–8
7) UK Social Prescribing – evidence
8) Taking action on the social determinants of health in clinical practice: a framework for health professionals
In episode 380, James and Mike continue celebrating their 10th podcasting anniversary with Tina K and Mike K and the silly studies and confusion continue to escalate.
Show notes
1) A randomized trial to assess the potential of different beverages to affect hydration status: development of a beverage hydration index.
Am J Clin Nutr 2016;103:717–23
2) Commercial features of placebo and therapeutic efficacy
3) Gender Roles and Pressure to be Truthful: The Bogus Pipeline Modifies Gender Differences in Sexual but Not Non-sexual Behavior
4) Kissing reduces allergic skin wheal responses and plasma neurotrophin levels
Physiology & Behavior 2003;80:395– 8
5) Longer Contact Times Increase Cross-Contamination of Enterobacter aerogenes from Surfaces to Food
Appl Environ Microbiol doi:10.1128/AEM.01838-16
6) Unskilled and unaware of it: how difficulties in recognizing one’s own incompetence lead to inflated self-assessments
J Pers Soc Psychol 1999;77:1121-34
7) Sexual Activity before Sports Competition: A Systematic Review
Front Physiol 2016;7:246. doi: 10.3389/fphys.2016.00246. eCollection 2016.
8) From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception
Acta Psychol 2015;160:58-68
9) The Relationships Among Height, Penile Length, and Foot Size
10) Honey bee sting pain index by body location
11) Can Sexual Intercourse Be an Alternative Therapy for Distal Ureteral Stones? A Prospective, Randomized, Controlled Study.
Evaluation of the efficacy of sexual intercourse in expulsion of distal ureteric stones.
Int Urol Nephrol 2017;49:27–30
12) The effect of acute increase in urge to void on cognitive function in healthy adults
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)
