In episode 243, Mike and James continue to delve into issues around industry and we now focus on how study design, selection of comparators and selective publication can impact the “truth”.
Show notes
1) Industry and us
In episode 242, Mike and James continue to delve into the impact industry marketing has on how and why we prescribe. We get to the evidence around many of the influences and at the end we realize we are all influenced by many things and we are all biased – so deal with it by being aware of the influence.
Show notes
1) Industry and us
In episode 241, Mike and James decide to delve into the impact industry marketing has on how and why we prescribe. We start off by discussing the theoretical issues surrounding the marketing of medications and briefly touch on the ethical dilemmas. At the end we realize we really haven’t discussed any evidence other than our own personal opinion and so we make a pact to discuss the evidence around this area in the next podcast.
Show notes
1) Industry and us
In episode 240, Mike and James target the information around hitting guideline targets. We talk about the futility of trying to get patients to all the thresholds and we end with discussing the problem of collateral damage when we all shoot for these targets.
Show notes
1) Tools For Practice
In episode 239, James, Mike and Adrienne get down and personal with the evidence around testosterone replacement. We find out very quickly that the data suffers from inconsistent results, small sample size, poor method description, lack of validated/useful endpoints, funding bias, and multiple outcome reporting – but other than that it is solid and all the answers are clear.
Show notes
1) Tools For Practice
Testosterone supplementation in men: Let’s pause for a moment
In episode 237, James and Mike, your PREMIUM podcasters bring you two new cardiovascular studies which show no benefit on cardiovascular outcomes and then we quickly finish off with great data on how long do colds and coughs last. The results may surprise you or maybe not.
Show notes
1) DESCARTES – A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia
NEJM 2014; DOI: 10.1056/NEJMoa1316222
2) TOPCAT – Spironolactone for Heart Failure with Preserved Ejection Fraction
N Engl J Med 2014; 370:1383-1392
3) How long does a URTI last in kids
BMJ 2013;347:f7027 doi: 10.1136/bmj.f7027
4) How long does an acute cough illness last?
In episode 237, James and Mike discuss even more listener questions. We cover issues around the SSRI withdrawal problem, warfarin, strep throat, NSAIDs, spironolactone, colchicine and a lot, lot more with less, less skill.
Show notes
1) SSRI discontinuation syndrome
In episode 236, Mike and James discuss the latest listener questions. We cover the flu shot, cardiovascular calculations and as always we deal with the never-ending questions about statins. At the end Mike, who has a cold decides to take a statin for his cold and the results will astound you.
Show notes
1) The best CVD risk calculator
2) What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice
In episode 235, Mike and James welcome Adrienne Lindblad who helps us sort out the issue of how many antiplatelets do you need after a stroke. We come to the conclusion that the evidence is really difficult to unclog, the answering is as clear as a plugged drain and if you get the title of this podcast you are very old.
Show notes
1) Tools For Practice
Anti-platelets after stroke: Are two better than one?
2) Surgery 101 – very clever audio/video podcast from a surgery gang from Edmonton, Alberta
In episode 234, Mike and James go PREMIUM all over again and discuss three new studies that were recently in the news. These studies looked at the link between fatty acids and coronary heart disease and acetaminophen use in pregnancy and ADHD. At the end of the podcast we decide to go out and eat a delicious meal and we forgot that we talked about an acetaminophen study.
Show notes
1) The Health Food Delusion
2) Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Ann Intern Med 2014;160:398-406
3) Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis
4) Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)
