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Episode 216: Questions that lead to questions and then more questions – Part IV

In episode 216, Mike and James finally get to the last of the listener questions. We discuss the numbers around the pneumococcal and influenza vaccines, metformin and contraindications, the timing of antihypertensives, and stuff for osteoporosis. Ironically we end with the question “does any of this mean anything in the grand scheme of things?” and we design a metaphorical RCT to answer that question.

Show notes

1) Metformin and harm

Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review

BMJ 2007;335:497

2) Metformin’s contraindications should be contraindicated

CMAJ 2005;173:502-4

2) MAPEC study

Chronobiol Int 2010;27:1629-51

3) Tools for Practice

Does calcium (Ca+) supplementation contribute to increased risk of myocardial infarction (MI) and other cardiovascular disease (CVD)?

4) CVD risk calculator

http://bestsciencemedicine.com/chd

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