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Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 44: Practice Changing Articles – with Double the Mikes

In Episode 44, we review another collection of practice changing articles and are joined by Dr. Mike Kolber. The first case and study considers the use of metformin in gestational diabetes and the trial leads to a longer discussion of the challenges of prescribing in pregnancy. The second case and study concerns the use of ondansetron for vomiting in pediatric patients. James interrupts the two Mikes frequently but never knows which one.

Show Notes

1) Metformin for gestational diabetes

NEJM 2008;358:2003-15

2) Glyburide for gestational diabetes

NEJM 2000;343:1134-8

3) Persistent pulmonary hypertension of the newborn

NEJM 2006;354:579-87

4) Risk of depression relapse in pregnancy

JAMA 2006;295:499-507

Lancet 2003;361:653–51

5) Vomiting in kids and ondansetron

Arch Pediatr Adolesc Med 2008;162: 858-65

Dosing: Ondansetron usually 1 dose: IV 0.15-0.3 mg/kg or oral 2-8 mg (range based on weight) or 1.6-4 mg (range based on age)

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