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Episode 483: Aducanumab for Alzheimer’s – forget about it?

In episode 483, James and Mike invite Tina to the podcast to talk about the aducanumab (Aduhelm) FDA approval story. We look at all the latest evidence, we talk about how people analyzed the data, whether or not the findings were clinically important, the side effects and finally the cost. And no matter how we looked at it we were still puzzled it got FDA approval. What do you think?

Show notes

1) Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis.

BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.n156 (Published 25 February 2021)

2) Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019

Alzheimers Dement. 2021 Apr;17(4):696-701.  doi: 10.1002/alz.12213.  Epub 2020 Nov 1.

3) Institute for Clinical and Economic Review

Aducanumab for Alzheimer’s Disease: Effectiveness and Value

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11th Annual PEIP Conference October 21-22, 2022

Practical Evidence for Informed Practice Conference | October 21 & 22, 2022
Led by the team that brings you Tools for Practice, the Practical Evidence for
Informed Practice (PEIP) Conference brings together clinical leaders to speak on
the latest findings that can affect how you practice.

www.peipconference.ca

BIG ANNOUNCEMENTS

THE NUTRITION PROPOSITION BOOK HAS JUST BEEN RELEASED

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

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BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

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