In episode 279, James and Mike invite Jon Ference to talk all about how he works smarter and not harder to answer clinical questions. During the podcast Jon exposes Mike’s and James’ ignorance on a number of things but we tolerate it because based on the best available evidence he seems like a nice guy.
Show notes
Information mastery – the beginning
In episode 278, James and Mike get back to being PREMIUM podcasters and we discuss new studies around drugs for COPD, pneumonia, and smoking cessation. At the end we catch our breath and look back at how breathtaking this PREMIUM podcast all about lung issues truly was.
Show notes
1) Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.
2) Antibiotic treatment strategies for community-acquired pneumonia in adults.
3) Risk of neuropsychiatric adverse events associated with varenicline: systematic review and meta-analysis
In episode 277, James and Mike finish off with the charming Adrienne Lindblad by discussing the issue of OCD and we discuss that it can be very debilitating and that some medications do have an effect but they also can cause side effects. At the end we all count to 100 backwards by 7s a dozen times – just for fun.
Show notes
In episode 276, James and Mike continue to enlist Adrienne Lindblad help with deciphering the literature surrounding anxiety medications. We discuss the evidence around buspirone and the benzodiazepines and wrap up the whole issue of what to use in GAD and at the end our anxieties disappear.
Show notes
SEE PREVIOUS PODCAST #275
In episode 275, James and Mike anxiously enlist Adrienne Lindblad to help us with deciphering the literature surrounding anxiety medications. We discuss the issue of anxiety scales in the studies, and look at the evidence around the use of antidepressants and antipsychotics for GAD.
Show notes
1) Tools For Practice
Atypical antipsychotics for anxiety: Worth worrying about?
Benzodiazepines in Generalized Anxiety Disorder: Calm Your Nerves?
In episode 274, Mike and James for a change look at the evidence behind two new drugs – one for over active bladder and one for depression and find unfortunately that as usual new drugs are no better than what we already have.
Show notes
1) Over active bladder drug
Mirabegron
Int Urol Nephrol 2014;46:275-84
2) Depression drug
Vortioxetine
In episode 273, Mike and James break down even more evidence around treatments for osteoarthritis. In this episode, we discuss topical NSAIDs, alternative therapies, narcotics and conclude, as in the previous podcast, that it is ultimately up to the patient to try to figure out what works best for them.
Show notes
In episode 272, Mike and James break down all the evidence around treatments for osteoarthritis. In this episode, we discuss activity, acetaminophen, NSAIDs and the benefits and harms around these treatments and at the end we come to the conclusion that it is ultimately up to the patient to try to figure out what works best for them.
Show notes
In episode 271, James and Mike discuss the most recent evidence for two new monoclonal antibody medications that lower lipids. We discuss the two new studies OSLER and ODYSSEY. At the end we both agree that it is great these studies looked at cardiovascular events and at least they are going in the right direction. However, we still have a long way to go before we would consider using them.
Show notes
Study synopses can be found at mystudies.org
DESCARTES
A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia
OSLER
Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
ODYSSEY LONG TERM
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
In episode 270, the Mikes and Tina and James stay viral, and discuss the best available evidence around the use of antiviral medications for treatment of the flu. At the end, we all agree there is an effect and that the person who should make the decision should be the patient once they have had the benefits and harms appropriately explained. Shared decision-making, a concept that is certainly nothing to be sneezed at.
Show notes
1) Tools for Practice
Anti-virals for Flu: Looking for evidence for “Stockpile, store, expire, repeat”
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
