Episode 36: Information on older drugs from an even older doctor – Part II

In episode 36, we take up where we left off in episode 35 by reviewing eight more (not ten) old drugs that hopefully you are still using – if not, get with the progam – in your day-to-day practice. Dr Bob joins us yet again for this episode and provides us with some great clinical experience and finally some reasonable humour. Mike tries to deliver some useful clinical pearls and James tries to keep things flowing smoothly – neither have tremendous success.

Show Notes

Nortriptyline

1) Chronic headache JAMA. 2001;285:2208-2215

2) Smoking cessation Antidepressants for smoking cessation. Cochrane Database of Systematic Reviews 2007, Issue 1

Fluoxetine

1) Weight loss in diabetics Arch Intern Med 2004;164:1395-1404

Metformin

1) Metformin’s contraindications should be contraindicated CMAJ 2005;173:502-504

Colchicine

1) Gout – uptake of colchicine into leukocytes Clin Pharmacol Ther 1993;54:360-7

2) Does colchicine work? The results of the first controlled study in acute gout Aust NZ J Med 1987;17:301-4 Br J Clin Pharmacol 1988;26:488-9

3) Pericarditis Arch Intern Med 2005;165:1987-91

4) Osteoarthritis Arth Care Res 2002;47:280-4 Osteoarthritis Cartilage 2002; 10:247-52

5) Cirrhosis NEJM 1988;318:1709-13

Vitamin B12

1) Oral vs IM Vitamin B 12 Fam Pract 2006;23:279-85

Iron

1) Low dose (15 and/or 50 mg) is as good as high doses (150mg) Am J Med 2005; 118: 1142-7

Nitroglycerin

1) Tennis elbow Am J Sports Med 2003;31:915-20

2) Acute pulmonary edema Amer J Emerg Med 1999;1716:571-4

3) Anal/bum fissures Lancet 1997;349:11-4

4) Raynaud’s Lancet 1982;1:76-7